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Saturday, November 19, 2011

Public Workshop – Magnetic Resonance Imaging Safety FDA

The Food and Drug Administration (FDA) is announcing a public workshop entitled: "Magnetic Resonance Imaging (MRI) Safety Public Workshop." The purpose of the public workshop is to discuss factors affecting the safe use of magnetic resonance imaging (MRI) and approaches to mitigate risks. The overall goal is to discuss strategies to minimize patient and staff risk in the MRI environment. The topics to be discussed are: general MRI safety, ferromagnetic detectors, scanning patients with medical implants, and the impact of innovation on MRI safety concerns. Additional background about Magnetic Resonance Imaging can be found at MRI (Magnetic Resonance Imaging).
The purpose of the workshop is to discuss factors affecting the safe use of magnetic resonance imaging (MRI) devices and approaches to mitigate risks.





Archived webcasts are currently available:

Contacts for Additional Information

For information regarding the program, contact:
Carol Krueger
Office of the Center Director
Center for Devices and Radiological Health
Food and Drug Administration
10903 New Hampshire Avenue
Bldg 66, Room 5437 br /> Silver Spring, MD 20993
Phone: 301-796-3241
Email: Carol.Krueger@fda.hhs.gov

Wednesday, November 16, 2011

CONTRAST ENHANCED MRA'S WITH ABLAVAR LOWER DOSES & BETTER RESULTS.

When I first heard from the sales rep at Lantheus that you could do a MRA Runoff with less than 10cc of Ablavar, I have to admit I was seriously doubtful. There is just something that seems inherently wrong there! We who have been in the field of MRI have been using much more for our power injected MRA's for a long time. I know over the last few years we have made strides to use the lowest dose possible but even this doesn't come close to what is possible with Ablavar. I am very happy with the results of Ablavar as a contrast agent for our MRA's. We have really been blown away with how well such a small amount of contrast works. the first pass Imaging looks great. The Steady State when done at high resolution can be such a nice addition to the study. the Ablavar will stay in the arteries and veins for about an hour after the injection. There is plenty of time for some High Res 576 matrix imaging. I am laughing to myself  because I know that a lot of you out there can do that routinely, on faster systems. I have a Old Siemens Symphony 1.5. but it runs good. and takes nice images still. Good luck trying Ablavar I know you will not be disappointed!










ABLAVAR®: unique chemistry at work
ABLAVAR® is a unique contrast agent specifically designed to overcome the limitations of MRA imaging with extracellular contrast agents.3
The ABLAVAR® difference is its reversible binding to the blood protein albumin.This binding allows ABLAVAR® to remain in the circulation (the “blood pool”) for up to 1 hour.1,3 As a result, high-resolution, finely detailed MRA images can be obtained in order to visualize the extent and severity of vascular pathology -- all with a single, low-dose injection.1,3,4
Only ABLAVAR® provides high-resolution, first-pass and steady-state images that, together, provide diagnostic accuracy comparable to XRA, with fewer uninterpretable images than both XRA and noncontrast-enhanced MRA.5,6
Efficacy
  • ABLAVAR® provides both bright, first-pass images and high-resolution, steady-state images for evaluating the location, extent, and severity of disease for appropriate intervention3,5,6
  • ABLAVAR®-enhanced MRA provides information that can impact diagnosis and patient management15,16
  • Phase 3 clinical trials prove that ABLAVAR®-enhanced MRA provides:
    • Diagnostic accuracy comparable to the reference standard XRA5,6
    • Fewer uninterpretable images than either XRA or noncontrast MRA5,6
Safety
  • Contains the lowest dose of gadolinium (70% less) of all of the gadolinium-based contrast agents used in MRA*1,7-11
  • No reported cases of nephrogenic systemic fibrosis in over 90,000 patients12
  • Documented safety and tolerability1,5,
http://www.ablavar.com/faqs.html............................. FAQ's

The dosing section will provide you with weight-based dosing guidelines for adult patients.
Imaging guidelines explain the timing of first-pass (dynamic phase) and steady-state (equilibrium phase) image acquisitions.
The system settings section will provide suggested system settings for Phillips, GE Healthcare, and Siemens system users. Depending upon the model used, your settings may vary.
Under additional resources, you will find relevant industry links.

Contact Ablavar Here

Title

Lantheus Medical Imaging, makers of ABLAVAR®, is committed to the professional and patient communities we serve. In the spirit of this commitment, we invite ongoing feedback and dialogue.
Address:
Lantheus Medical Imaging, Inc.
Bldg. 200-2
331 Treble Cove Rd.
N. Billerica, MA 01862
Phone: (800) 362-2668 (for Massachusetts and International, call (978) 667-9531)
Fax: (978) 436-7501
Adverse Event and Product Quality Complaint Reports
United StatesOutside US/Canada
Phone: (800) 343-7851
  • Press Option 2 for Adverse Events
  • Press Option 3 for Product Quality Complaints
Fax: (866) 880-9343
Phone: (978) 667-9531
  • Press Option 2 for Adverse Events
  • Press Option 3 for Product Quality Complaints
Fax: (734) 929-6688
E-mail: lantheussafety@i3drugsafety.com
Medical Information
For adverse events and product quality complaints, please use contact information above. 
Phone: (800) 343-7851
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Fax: (978) 671-8736
Hours: 8:30 AM to 4:30 PM Eastern Time, Monday to Friday
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Phone: (800) 299-3431
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Hours: 7:30 AM to 6:30 PM Eastern Time, Monday to Friday
Sales
If you would like a sales representative to contact you, please complete the form below.
Sponsorship & Grants
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Linda Lennox Lantheus Medical Imaging
Phone: (978) 671-8854

Wednesday, November 09, 2011

MRI Safety and the FDA




Why FDA and ACR Are Concerned With MRI Safety?
Nearly everyone who works around magnetic resonance imaging (MRI) has heard of or experienced incidents involving ferromagnetic projectiles. As the number and strength of MRI scanners in the nation’s hospitals has increased from a handful, 20 years ago to about 10,000 today, ferromagnetic accidents have become more frequent. Some have caused serious injuries and even death.
“The proliferation of MRI equipment and significant increases in both magnet strength and spatial gradients… have increased the number of accidents occurring in the MRI suite. Each accident and close call puts patients and staff at risk and carries the potential of damaging, if not crippling, over a million dollars worth of imaging equipment.”
Tobias Gilk, M . Arch., a member of ACR’s MR Safety Committee –
(Patient Safety & Quality Healthcare, September/October 2006)
Many experts in the area of MRI safety believe that a major factor in the failure to address safety issues in the MR environment is a gross underestimation of the risk.
“…there is a strong ‘it couldn’t happen here’ mentality. …I don’t believe people are quite aware of the potential problems that can occur, the substantial severity that could occur.”
Emanuel Kanal, MD, FACR, FISMRM, AANG – (Good Morning America, abc News 08/22/05)
“Each scanner would have a serious accident about once every 5 years.”
Chaljub et al (From the Study of the University of Texas Hospitals)
Even with a doubling of MRI safety incidents reported in the 12 month period ending mid-2006 from the previous one-year period and despite the reporting requirements, it is believed that fewer than 10% of MRI accidents are reported. No one knows how many have truly occurred. However, MRI safety specialists say there is no doubt they are on the rise. More than half of the reported accidents involve ferromagnetic projectiles. This vast underreporting prevents imaging providers in using the much needed information to make effective decisions to prevent future accidents. Furthermore, it serves to stigmatize those who admit to having had MRI safety mishaps. Therefore, there is no learning from the past.
According to a survey performed by Dr. Chaljub and colleagues in 1999, which was sent out to 250 imaging facilities across the US asking about the occurrence of MRI-related accidents, 52% of responses reported airborne objects: a defibrillator, a wheelchair, a respirator, ankle weights, an IV pole, a toolbox, sandbags containing metal pellets, a vacuum cleaner, and mop buckets.
Risk Increasing Factors
A number of factors are contributing to the ferromagnetic projectile risk and its increase. Most of the below mentioned issues are listed in “The VA National Center for Patient Safety MR Alert” summary:
  1. With the increased use of higher strength field magnets and self shielded magnets, the maximum force of attraction increases dramatically.
  2. The increase of spatial gradients of the new active shielded magnets:
    • No gentle, slowly increasing pull to provide feedback of ferromagnetic properties
    • Maximum force much greater than for the same field strength unshielded magnet
    • Distance/Time to react to force can be shorter than reaction time
    • A 3T magnet with the same magnetic footprint as a 1.5T has four times the force
  3. MRI magnets are always ON, therefore projecting the magnetic field, which can be as much as 60,000 times more powerful than the Earth’s, 24/7. Equipment and consumables that are “safe” 99% of the time become “unsafe” near MRI
  4. The large invisible magnetic field that is projected by an MRI machine and extends in 3 dimensions cannot be touched, seen, smelled, or sensed in any other way.
  5. Many objects that are “seemingly safe” and appear not to contain iron or any other ferromagnetic materials, for example, sandbags can contain ferrous materials even though one would not think so.
  6. Non MR staff in MRI suite, for example, cleaning personnel or the family members accompanying patients.
  7. Labeling on devices or in documentation can be confusing: “MR safe”, “MR not safe” and “MR conditional” - these terms are not intended to be used without further specifying the particular MR environment conditions where the devices have been tested.
  8. Sharing imaging staff between different modalities. What can be safe in CT environment can become very dangerous in MR environment.
  9. In case of emergency, if you need to shut off the MRI magnet, there can be health hazards and $20,000-$500,000 cost associated.
  10. Combination of complacency, work-arounds for speed, and diffuse responsibility
Regulatory Actions
In July, 2007 the FDA’s Patient Safety News video program acknowledges the ongoing effort to combat accidents and injuries in the MRI suites. The FDA states: “Unfortunately this problem has not gone away. MR associated accidents, many of them life threatening or fatal are still occurring, causing continued concern in the radiology community.” Furthermore, the FDA recognizes and highlights the recently updated “ACR Guidance Document for Safe MR Practices: 2007”
“It’s important to have and read this document” – FDA.
This year a wholly rewritten document, retitled the “ACR Guidance Document for Safe MR Practices: 2007,” has been dramatically expanded to offer a new safety standard for MRI suites. Consistent with the proceeding issues of the 2007 guidance document, the ACR reaffirms the application of the four-zone principle in laying out MRI suites. Under this principle, a person must successfully complete sequential levels of screening before they are cleared to proceed from areas with zero risks associated with MRI magnetic fields to the MRI magnet itself.
It is important to note that the new standards were unanimously approved by all committee members, which includes professionals form a broad spectrum of specialties, such as: MR physicists, research/academic radiologists, private practice radiologists, MR safety experts, patient safety experts/researchers, MR technologists, MR nursing, National Electrical Manufacturers Association, the U.S. Food and Drug Administration (FDA), the American Society of Anesthesiologists, legal counsel, and others.



Costly projectiles
Projectile-related accidents also can be very costly. Gilk cited a study from the U.S Department of Veterans Affairs' National Center for Patient Safety, which conducted a cost analysis of a projectile accident. It found that such events have an average cost of $43,172 per occurrence, based on the expense to repair the MRI scanner and legal settlements associated with an injury to a patient or staff person.
The total did not include downtime for the machine and lost revenue. "If the hospital is making, on average, $650 to $700 on technical revenue per MR exam and the machine is down for three days, [the facility] will miss 20 to 30 exams over that time, and that gets very expensive very quickly in terms of lost revenue," Gilk added.
As for hearing loss, facilities should provide patients with earplugs to prevent ear damage, and instruct patients on how to insert them properly. It may sound like a simple task to insert ear plugs, but not everyone's outer ear anatomy is the same, and one size does not fit all.
Kanal added that adverse events can be prevented by establishing and maintaining consistent MRI safety education among healthcare practitioners so they are aware of the potential risks that could occur throughout the MR imaging process. In addition, there should be "adequate MRI site access restriction and supervision by MRI healthcare professionals over patients and other non-MR personnel," he said.
Training personnel
Training is a critical ingredient to reducing the number of accidents in the MRI environment. Shellock maintains the website MRIsafety.com, as well as a site for the Institute for Magnetic Resonance Safety, Education, and Research (IMRSER.org). The website features safety information and streaming training programs for patients, nonmedical personnel, MRI technologists, and radiologists.
Training for nonmedical personnel, such as maintenance staff, housekeeping staff, and security officers, on how to conduct themselves in the MRI setting is just as important as it is for MRI technologists and radiologists. Nonmedical employees may not realize that an MRI scanner is always energized, or "on," and have been responsible for projectile and other accidents at some facilities.
Shellock said there are no data available to determine if nonmedical employees cause more projectile accidents than professional healthcare staff, but they do "make up a fair number of the problems that have occurred."
Education and training programs need to be conducted on a regular basis, and MRI facilities "have to make a concerted effort to train anyone who works in and around the MRI setting," Shellock added. "It has been our motivation to put together these comprehensive programs. Now it is a matter of disseminating the information and making sure people understand that these programs do exist and they are able to access them."
While the use of ferromagnetic detection systems to prevent projectile incidents is widely recommended, Shellock noted that there are no current data or peer-reviewed literature on the technology's efficacy. He and his colleagues are preparing to evaluate ferromagnetic detection systems to determine the benefits of their use.
The FDA's safety workshop also plans to consider the issue of MRI safety for patients with implanted devices. Inconsistencies in labeling information for those devices are a major concern, according to Shellock. "That can cause a lot of confusion, and we often see MRI technologists and radiologists who may elect not to scan the patient," he added. "That is a disservice to the patient."


One of the “ACR Guidance Document for Safe MR Practices: 2007,” updates concentrates on ferromagnetic screening. And now for the first time recommends the use of ferromagnetic detectors for all MRI facilities. The entire document can be accessed through these links:
http://www.ajronline.org/aheadofprint/AJR_06_1616.dtl or,
http://www.acr.org/mr_safety

Wednesday, August 17, 2011

MRI and Von Hippel-Lindau Disease


Von Hippel Lindau disease (VHL) is an inherited mutation of the VHL gene, which causes tumors to form in areas of the body that contain large numbers of blood vessels. One in every 32,000 children born in the U.S. is affected by VHL.
Von Hippel Lindau (VHL) disease was first described at the beginning of the 20thcentury by Eugen von Hippel and Arvid Lindau. A mutation of the VHL gene can affect several organs of the body, and can be expressed differently in every patient and every family. The most common manifestations of VHL include cysts and tumors of the retina, brain, spinal cord, kidney, pancreas and inner ear.
Patients with VHL can present with cerebellar hemangioblastomas, retinal hemangioblastomas, pheochromocytomas, kidney cancer, pancreatic cysts and pancreatic neuroendocrine tumors.
The University of Texas: MD Anderson Cancer Center

MD Anderson Resources

Call askMDAnderson
1-877-MDA-6789

Imaging in Von Hippel-Lindau Syndrome

  • Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR; Chief Editor: James G Smirniotopoulos, MD   more

Overview

Grouped as a hereditary phakomatosis, von Hippel-Lindau syndrome (VHL) is an autosomal dominant, inherited, neurocutaneous dysplasia complex with an 80-100% penetrance and variable delayed expressivity. Sex distributions are equal, and 20% of cases are familial. Images of VHL are shown below,
von Hippel-Lindau syndrome. Transaxial nonenhancedvon Hippel-Lindau syndrome. Transaxial nonenhanced and contrast-enhanced CT scans through the cerebellum in a 34-year-old patient with a family history of VHL. Scans show a midline cerebellar cystic lesion with an enhancing nodule (arrow) due to cerebellar hemangioblastoma.von Hippel-Lindau syndrome. T1-weighted transaxialvon Hippel-Lindau syndrome. T1-weighted transaxial gadolinium-enhanced MRIs of the same patient as in the previous image show a well-defined hypervascular enhancing mass.von Hippel-Lindau syndrome. Coronal vertebral angivon Hippel-Lindau syndrome. Coronal vertebral angiogram of the same patient as in the previous 2 images shows a hypervascular intramural nodule that demonstrates a prolonged and intense enhancement with a surrounding avascular area, which represents the cyst surrounding the mural nodule. Note the stretching around the cyst.von Hippel-Lindau syndrome. Sagittal vertebral angvon Hippel-Lindau syndrome. Sagittal vertebral angiogram of the same patient as in the previous 3 images shows a hypervascular intramural nodule (open arrow) that demonstrates a prolonged and intense enhancement with a surrounding avascular area, representing the cyst surrounding the mural nodule (solid arrows). Note the stretching of vessels around the cyst. The final diagnosis was a cerebellar hemangioblastoma associated with von Hippel-Lindau syndrome (same patient as in Images 1-3).VHL is characterized by a predisposition to bilateral and multicentric retinal angiomas, central nervous system (CNS) hemangioblastomas; renal cell carcinomas; pheochromocytoma s; islet cell tumors of the pancreas; endolymphatic sac tumors[1] ; and renal, pancreatic, and epididymal cysts.[2, 3] CNS hemangioblastoma (Lindau tumor) is the most commonly recognized manifestation of VHL and occurs in 40% of patients.[4]
Symptoms often begin in the second to third decades of life. Patients may present with ocular signs and/or symptoms due to retinal hemorrhage, retinal detachment, glaucoma, or uveitis. Funduscopic examination may reveal tortuous aneurysms of the retinal vessels, exudates on the fundus, and subretinal yellowish spots. Patients may present with neurologic symptoms such as headaches, ataxia, and blindness. The exact neurologic deficit depends on the site of the primary lesion.

Magnetic Resonance Imaging

Hemangioblastomas occur throughout the CNS, but they have several favored locations, including the cerebellum (most common site), medulla, spinal cord, and retina. Although hemangioblastomas can occur as isolated tumors, retinal tumors are mostly confined to VHL.[13, 11, 12]
MRI appearances of a hemangioblastoma are those of a well-demarcated cystic lesion with a highly vascular mural nodule that abuts on the pia mater.
Appearances of the cystic component vary depending on the protein concentration and/or presence of hemorrhage within the cyst. The cystic component may be isointense relative to cerebrospinal fluid (CSF) on images obtained with all pulse sequences, but more often, it is slightly hyperintense relative to CSF on T1- and T2-weighted images.
Mural nodules are slightly hypointense on T1-weighted images and hyperintense on T2-weighted images, and they are avidly enhancing after the administration of contrast material.
Large feeding or draining vessels are often present at the periphery and within the solid component, and they may show tubular areas of flow void on spin-echo images.
Although the lesion is benign, it may resemble malignant lesions on advanced MR images. It may have elevated relative tumor blood volume on perfusion MR. Similarly, it may show elevated choline on MR spectroscopy.
Endolymphatic sac tumors are heterogeneous on both T1- and T2-weighted images. They are associated with focal high signal intensity on T1-weighted images due to subacute hemorrhage and with areas of low signal intensity due to calcification or hemosiderin.
Blood and protein-filled cysts have high signal intensity on both T1-weighted and T2-weighted images; a finding of these cysts may suggest the diagnosis.
Tumors larger than 2 cm may have flow voids.
After the administration of contrast material, the tumor enhances heterogeneously.
On MRIs, choroidal capillary hemangiomas associated with VHL are minimally hyperintense on T1-weighted images. They may mimic ocular melanoma, but unlike pigmented melanoma, they are usually hyperintense on T2-weighted images.
As a result of the small size of retinal hemangiomas (1.5-2.0 mm), they are usually not identified on MRIs.
Spinal hemangioblastomas are intramedullary tumors in most patients (75%), but they may be radicular (20%) or intradural extramedullary (5%). Most of these tumors are located in the cervicothoracic spine. They usually expand the cord and have an intratumoral cystic component. On MRIs, they appear as a well-demarcated gadolinium-enhancing mass. Spinal hemangioblastomas are an unusual cause of cryptic subarachnoid hemorrhage. Patients with subarachnoid hemorrhage with negative cerebral angiography may benefit from contrast-enhanced spinal MRI to rule out an occult spinal hemangioblastoma.
An intramural nodule that enhances intensely may be visible. Large dorsally placed draining veins may appear as curvilinear areas of signal void. A syrinx is a frequently associated finding.
A pheochromocytoma associated with VHL has MRI appearances no different from those of the sporadic form. The tumor appears isointense or slightly hypointense relative to the liver on T1-weighted images, and it is extremely hyperintense on T2-weighted images.
Magnetic resonance images of von Hippel-Lindau syndrome are depicted below.
von Hippel-Lindau syndrome. Coronal T1-weighted MRvon Hippel-Lindau syndrome. Coronal T1-weighted MRI shows an enhancing lesion in the right cerebellar hemisphere compressing and displacing the aqueduct and fourth ventricle to the left. Note the tubular areas of flow void resulting from large blood vessels and the cystic tumor component.von Hippel-Lindau syndrome. Coronal T1-weighted MRvon Hippel-Lindau syndrome. Coronal T1-weighted MRI (same patient as in the previous image) shows an enhancing lesion in the right cerebral hemisphere that compresses and displaces the aqueduct and fourth ventricle to the left. Note the tubular areas of flow void resulting from large blood vessels.von Hippel-Lindau syndrome. Oblique coronal T1-weivon Hippel-Lindau syndrome. Oblique coronal T1-weighted gadolinium-enhanced MRI through the right kidney shows a hypointense linear mass extending from the renal capsule to the renal pelvis. At surgery, a renal cell carcinoma was confirmed.von Hippel-Lindau syndrome. Coronal T1-weighted covon Hippel-Lindau syndrome. Coronal T1-weighted contrast enhanced MRI shows an intensely enhancing cerebellar lesion (red arrow) with a large cystic tumor component (white arrow).von Hippel-Lindau syndrome. Coronal T1-weighted covon Hippel-Lindau syndrome. Coronal T1-weighted contrast enhanced MRI (same patient as in the previous image) shows, at lower sections, an intensely enhancing cerebellar lesion with a large cystic tumor component. Note also the enhancing mural nodules and intratumoral flow void due to large pathological vessels.von Hippel-Lindau syndrome. Sagittal T2-weighted Mvon Hippel-Lindau syndrome. Sagittal T2-weighted MRI (same patient as in the previous 2 images) shows a cerebellar lesion with a large septate cystic component (arrow). Note the hydrocephalus.von Hippel-Lindau syndrome. Sagittal T2-weighted Mvon Hippel-Lindau syndrome. Sagittal T2-weighted MRI (same patient as in the previous 3 images) shows a cerebellar lesion with a central low signal component related to intratumoral hemorrhage.von Hippel-Lindau syndrome. Axial T2-weighted MRI von Hippel-Lindau syndrome. Axial T2-weighted MRI shows high signal nodules in the region of previous surgical resection of hemangioblastoma in an 18-month surveillance scan. An earlier scan showed no nodular lesions in this region. The appearance suggests a recurrence of hemangioma.von Hippel-Lindau syndrome. Axial T2-weighted MRI von Hippel-Lindau syndrome. Axial T2-weighted MRI (same patient as in the previous image) shows high signal nodules in the region of previous surgical resection of hemangioblastoma in an 18-month surveillance scan. An earlier scan showed no nodular lesions in this region. The appearance suggests a recurrence of hemangioma.

Gadolinium warning

Gadolinium-based contrast agents (gadopentetate dimeglumine [Magnevist], gadobenate dimeglumine [MultiHance], gadodiamide [Omniscan], gadoversetamide [OptiMARK], gadoteridol [ProHance]) have been linked to the development of nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy (NFD). The disease has occurred in patients with moderate to end-stage renal disease after being given a gadolinium-based contrast agent to enhance MRI or MRA scans.
Characteristics of NSF/NFD include red or dark patches on the skin; burning, itching, swelling, hardening, and tightening of the skin; yellow spots on the whites of the eyes; joint stiffness with trouble moving or straightening the arms, hands, legs, or feet; pain deep in the hip bones or ribs; and muscle weakness.

Degree of confidence

MRI is the modality of choice for imaging the central nervous system in patients in whom hemangioblastoma is suggested and for screening asymptomatic patients with VHL and their relatives at risk for VHL.

False positives/negatives

False-positive diagnoses may occur with cystic astrocytomas, which are usually smaller than 5 cm in diameter; these may be calcified, and they usually have thicker walls. Cystic metastases occasionally resemble a hemangioblastoma superficially. Spinal hemangioblastomas must be differentiated from intramedullary hemorrhage.
Endolymphatic sac tumors may mimic other cerebellopontine tumors. Nonfunctioning adrenal adenomas, adrenocortical adenomas, and adrenal cysts must be differentiated from pheochromocytomas associated with VHL.

GE’ 3T MRI scanner MR750


Simply Powerful, Powerfully Simple It’s MR beyond boundaries, giving you every edge. Break free from traditional 3.0T scanning – powerfully, precisely, productively. Just for starters, we’re talking about a complete liver study in a 15-minute time slot, or the breast images you need in only two sequences. No more “what ifs” – it’s time for “right nows.”

The strongest whole-body gradients – the most powerful in the industry – and the new gold standard in body, breast and MSK imaging… now that’s powerfully simple MR.

 

 

Break the Bonds: Start from a Position of PowerThe Signa® MR750 3.0T’s stunning new technologies take 3.0T imaging to a new level. This remarkable technology allows you to focus on what’s most important – patients.

The most reliable 3.0T magnet, the Signa® MR750 3.0T is built around GE’s third-generation short-bore, superconducting 3.0T magnet – proven to deliver high homogeneity for excellent results…even in large or off-center FOV imaging, fat saturation techniques and high-performance applications such as cardiac, fMRI, diffusion tensor and spectroscopy. Other technical breakthroughs include:

  • Sophisticated real-time SAR optimization.

  • Unique heat extraction gradient architecture for faster acquisitions and fewer slowdowns.

  • Exclusive OpTix optical RF technology for greater SNR.

  • ARC, accelerated parallel imaging.

  • Faster reconstructions.

  • Anatomy-optimized RF coils and arrays.

  • Easily scalable for future expansion.

 

 

Break Away: Routine Exams Faster, Advanced Exams Routine

As the most efficient scanner available, every scan is a study in speed. Conduct in-room patient set up in as little as 30 seconds and start scanning in just a few simple steps. The Signa® MR750 3.0T makes routine exams faster than the industry standard, and advanced exams routine.

 

The Signa® MR750 3.0T is designed around clinical workflow needs with a strong focus on improving productivity, such as:

  • Automated clinical applications mean fewer steps to faster studies.

  • A high-resolution color in-room operator console (iROC) equals quick exam set up.

  • The Express Patient Table offers one-time patient transfer, comfort and operational efficiency. Two 32-channel surface coil connections integrated right into the table can simplify patient preparation outside the scanning room.

  • With a simple, one-handed motion, the integrated arm boards can be optimally positioned to support the patient for injections and transport.

  • Located to the left and right of the scanner bore, the dual-sided controls let you operate the scanner from either side of the patient table.

  • Start scanning in just a few simple steps with IntelliTouch patient positioning.

  • The system gives patients a quick, easy, and comfortable MR experience.

The strongest whole-body gradients – the most powerful in the industry – deliver incredible 50mT/m gradient field on each axis (X, Y and Z) simultaneously, plus a slew-rate of 200 T/m/s combined with OpTix – an exclusive optical RF technology. The result: higher accuracy and more reproducible scans. Additionally, you’ll experience up to 60% more anatomical coverage and resolution per unit time, 27% more SNR and faster reconstruction speeds. What’s more, enjoy the new gold standard in body, breast and MSK imaging.

Clinical Break Down: Fresh Vision, New Clarity

Thanks to unprecedented temporal system stability and high signal-to-noise, the subtle brain activation signal treats in the foreground and can be captured much more reliably. The Signa® MR750 3.0T delivers routine, accurate, repeatable fMRI studies with 60% more spatial resolution in the same scan time and with reduced number of paradigm repetitions.
Combining multiple series into one, VIBRANT – IDEAL helps reduce exam time and ensure “can’t miss” fat suppression in breast studies. With no need for shimming and ARC parallel imaging on the Signa® MR750 3.0T, your productivity benefits are substantial.

This system is ready for clinical prime time. Read about the details behind this remarkable technology.

  • With Cube, you can more easily reformat sub-millimeter isotropic 3D volume image data from a single acquisition into any plane-axial, sagittal, coronal or oblique – with no gaps or loss of resolution. New, self-calibrated ARC parallel imaging engine speeds up the acquisition, while eliminating aliasing even in small FOV imaging.

  • 3D MERGE: Generating excellent gray-white matter contrast in the spinal cord without sacrificing SNR, this high-definition, 3D application acquires 1 mm slices in a clinically relevant scan time, enabling reformats in different planes.

  • Time of Flight imaging on the Signa® MR750 3.0T gives you more -more spatial resolution and more contrast between the flowing blood and the surrounding tissue- for more small vessel detail more confident diagnoses.

  • Providing exceptionally uniform, consistent fat suppression across the entire image in a very large field of view, LAVA-IDEAL produces four contrasts in just one acquisition, for confident diagnoses and fewer repeat exams.

  • Now delivering improved performance, which lets you more than double the slices or alternative to acquire more diffusion directions in the same scan time, DTI/FiberTrak lets you visualize white matter trajectories in the brain.

Tuesday, August 09, 2011

Anyone using Toshiba magnets please comment about your experience. Good or bad. Thank you! I think this new magnet will be a nice one!!

Vantage Titan 3T

Titan 3T sets new standards in Comfort, Imaging and Productivity
Experience 3T like never before!
With Toshiba’s Titan series, you provide unsurpassed comfort to your patient, combining a short 1.6 meter magnet with a large 71 cm opening, reducing patient anxiety and allowing 80% of the body to be scanned feet first.

The widest…
What do 71 cm bring in practice?
More comfort for your patients
Helps against claustrophobia
More space to fit patients of all sizes
Reduce stress and anxienty
Easy check-on and access-to your patient
Ideal for pediatrics and geriatrics
Ideal for breast imaging
The quietest…
Acoustic noise is an important source of problems on conventional MR systems. It makes communication with the patient difficult and causes the patient discomfort. It can induce transient or permanent hearing disturbance and also poses a hazard for pediatric patients who need sedation.

Toshiba’s unique PianissimoTM technology has been further improved
and applied to provide the quietest 3T system available.
Read more about PianissimoTM

Magnetic Field Homogeneity: B0
While conventional MR systems offer a spherical homogeneous are centered at the iso-center of the scanner, a cylinder corresponds better to the form of the human body. With conform technology, Titan 3T offers a 50 x 50 x 45 cm cylindrical homogeneous Field Of View.

RF Field Homogeneity: B1
Titan 3T uses optimized amplitude and phase transmission called “Multi Phase Transmit”. It has the functionality of a Multi-channel Transmit Array, using multiple ports and multiple phases for optimal B1 homogeneity. It removes shading artifacts, improves SAR and reduces scan times by up to 40%.

Exceptional Contrast Resolution
With Conform and Multi-Phase Transmit technologies, abdominal and pelvic imaging are no challenge on Titan 3T. No more shading on your T2-weighted (fast) spin echo images. No more uneven fat suppression on your images. You can use SSFP from head to toe!

Image on the right:
T2-W FSE (0.5×0.5×2.5mm)

Atlas matrix coil system
In conventional MR systems, the organ specific coils require frequent coil exchange. The heavy weight of most coils makes the task tedious for the operators and the time devoted to this operation is wasted. With Atlas, coil exchange is dramaitically recuced and the few times it is required, the light weight of the coils makes it a fast and easy operation. This way, the workflow is significantly increased.
Read more about Atlas

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brochure!











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Thursday, March 10, 2011

The new Eovist Liver Lesion Library.

Liver Lesion Library

EOVIST® (gadoxetate disodium) Injection

Liver Lesion Library

Redefining Liver Imaging

The EOVIST Liver Lesion Library provides over 700 images along with detailed case studies documenting the use of EOVIST in hepatocyte phase imaging.
EOVIST Liver Lesion Library

INDICATIONS and IMPORTANT SAFETY INFORMATION

EOVIST® (gadoxetate disodium) Injection

INDICATIONS AND USAGE

EOVIST® (gadoxetate disodium) Injection is a gadolinium-based contrast agent indicated for intravenous use in T1-weighted magnetic resonance imaging (MRI) of the liver to detect and characterize lesions in adults with known or suspected focal liver disease.

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